Brandon Case

Brandon studied chemistry as an undergraduate at Western New England University where he became interested in enzymatic reactions during research with Dr. Anne Poirot. To continue his study of enzymes, he pursued a PhD at Wesleyan University in Molecular Biology & Biochemistry with Dr. Manju M. Hingorani. At Wesleyan, Brandon learned to uncover molecular mechanisms using transient kinetic assays. His graduate research focused on understanding the initiation of bacterial DNA mismatch repair (MMR) and nucleotide excision repair (NER), in which MutS and UvrA2 mechano-chemically couple their actions with ATP hydrolysis to initiate DNA repair. During this work, Brandon developed an interest in single-molecule experiments to expand his ability to understand molecular mechanisms. This led him to join the Loparo Lab, where he now studies end processing during non-homologous end joining using single-molecule techniques. Outside of lab, Brandon enjoys spending time with his family, cooking, and astronomy.