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About Us

We are an interdisciplinary group of scientists with backgrounds in protein biochemistry, biophysics, molecular biology and chemistry. Our primary focus is elucidating the molecular mechanisms of genome maintenance, although we are always interested in expanding the scope of biology we investigate through collaboration. To this end, we use a multidisciplinary approach that employs biochemical, genetic and single-molecule assays in both in vitro and cellular systems. 

Our Mission

Fundamental discoveries in biological mechanism
We are interested in how biology works at the molecular level. You can learn more about our current research interests here. Ultimately, we aim to leverage these advances in mechanistic biology to identify novel therapeutic targets. 

Developing new approaches to probe structure and function
We are committed to developing single-molecule approaches that probe biological machines with increasing molecular resolution.  If you want to learn more about these approaches check out our Tools page.

    Training the next generation of rigorous and creative scientists
    Training and supporting lab members is an essential part of our mission. All trainees meet with Joe at least once a year to discuss long term goals and collaboratively identify training gaps and goals. Areas of emphasis include: scientific presentation & writing, mentoring & teaching, experimental & computational approaches and other professional development opportunities.

    Our Values

    Respect and Collaboration
    We strive to create an environment where every member is appreciated for their unique experiences, skills and ideas. Given our diverse research backgrounds, we actively foster the exchange of ideas between lab members. To that end, we meet weekly as a group and also in subgroups to discuss experimental progress and challenges. While each lab member has their own project, lab members are encouraged to work together to solve common problems. 

    Rigorous Investigation
    We emphasize quantitative experimental approaches and analysis to ensure that our results are reproducible and interpretable.  

    Have fun! 
    Experimental science is hard, and at times frustrating, but no one said you can't have some fun in the midst of challenges. We are especially proud of our posters for BCMP Happy Hour, some of which are featured in the gallery below. 

    Our Laboratory

    We share an open concept laboratory on the second floor of the Seeley G. Mudd building with the laboratories of Andrew Kruse and Johannes Walter.